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Clostridium difficile and its toxins

Clostridium difficile and its toxins
Saleem Hafiz

1974

Department of Botany, University of Leeds, Leeds LS2 9JT, UNITED KINGDOM.

ABSTRACT

An investigation of Clostridium difficile has shown :

1. that the organism is resistant to cresols and phenolq and may be grown from material grossly contaminated with other organisms by culture in media containing these substances; strains isolated before this method was evised are also resistant to cresols and phenol;
2. that the organism divides into four daughter cells;
3. that each strain examined has a different strain specific agglutinogen, and that the strains are otherwise antigenically complex;
4. that the sugar reactions are fairly consistent;
5. that gelatin is liquefied by all available strains in three weeks; and that apart from this there is no proteolytic activity;
6. that the hyaluronidase produced by all strains is antigenically uniform? and so is the lethal toxin;
7. and that the 'haemolysin' is almost certainly complex.